E-mail: ipep_pharma@ukr.net

MAIN AREAS OF SCIENTIFIC ACTIVITY:

• screening of new biologically active compounds;

• experimental study and assessment of the influence of biologically active compounds (biological preparations and drugs of synthetic origin) on the functional activity of the thyroid gland in thyropathies of various genesis and associated metabolic disorders in the musculoskeletal system, immune, cardiovascular and reproductive systems under different conditions thyroid hormone levels;

• preclinical study of original chemical compounds and biological preparations that can be considered as potential drugs for the correction of functional disorders of the thyroid gland and metabolic disorders associated with thyropathies;

• preclinical studies of specific action, chronic and subchronic toxicity of other potential medicinal products;

• substantiation of directions for gender-specific prevention and therapy of thyropathies of various genesis.

MAIN ACHIEVEMENTS

For a long time, the laboratory has been studying the effect of biologically active compounds of various origins on the functional state of the thyroid gland in hypo- and hyperthyroidism and AIT and metabolic disorders in the musculoskeletal system, immune, cardiovascular and reproductive systems associated with thyropathies under conditions of excess and deficiency of thyroid hormones.

Screening testing for specific thyrotropin activity of more than 150 new biologically active compounds synthesized at the SI "IEPP NAMS" was carried out. As a result of the research, a number of highly active, low-toxic compounds with thyrostatic, thyroid-stimulating and immunomodulatory activity were discovered, which in the future can be considered as potential harmless drugs of the new generation.

The expediency of using biological preparations of the embryo-fetoplacental complex in the complex therapy of hypothyroidism and autoimmune thyroiditis has been experimentally substantiated. 3 patents of Ukraine were obtained for the methods of correction of thyroid insufficiency with the help of biological preparations.

The prospect of further study of the original chemical compound with thyroid-stimulating activity and pleiotropic action as a potential drug for restoring the function of the thyroid gland in the correction of hypothyroidism has been proven. 2 Ukrainian patents were obtained for the biologically active substance.

Sexual characteristics of changes in the histostructure and function of the thyroid gland during the creation of an experimental model of mercazolyl hypothyroidism in rats were established.

SCIENTIFIC ACTIVITIES OF THE LABORATORY.

The laboratory carries out scientific activities, as a result of which master's, candidate's and doctoral theses are protected.

In 2019, Yuliia Kurylko was scheduled to write a dissertation for the PhD "Experimental determination of the effect of cord blood biological preparation on the functional activity of the thyroid gland and the immune system in rats under the conditions of modeling autoimmune thyroiditis." Currently, this work is undergoing internal approval.

In 2021, the doctoral thesis of Nataliia Brechka was defended. "The role of connective tissue in the formation of hormonally determined reproductopathies in males (experimental study)".

In 2021, research was planned and conducted within the framework of the dissertation work of Larysa Syrotenko. "New approaches to the correction of hypothyroidism of various genesis with non-hormonal biologically active compounds".

In 2022, the scientific research work (SRW) of the Academy of Medical Sciences 03.20 "Development of new approaches to the correction of autoimmune damage to the thyroid gland based on the means of regenerative medicine in the experiment" was completed.

From 2023, the scientific research work (SRW) of the Academy of Medical Sciences 03.23 "Experimental determination of the effect of cord blood biological preparation on the functional activity of the thyroid gland and the immune system in rats under the conditions of modeling autoimmune thyroiditis" is being carried out.

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